Immediately following the second dose, we will have 12.5 mg/L remaining from the original dose, plus an additional 50 mg/L resulting from the second dose that was just administered. What if a second 500 mg dose is given at the six-hour mark? For most drugs, the concentrations produced by this second dose would be comparable to concentrations produced by the first dose. However, at the six-hour time point we still have 12.5 mg/L of drug remaining from the first dose, as described above. If no further doses are administered, the concentration will continue to decline by an additional 50% every three hours. If our hypothetical drug has a half-life of three hours, we will observe a concentration of: We frequently describe this decline in terms of half-life (the time required for drug concentration to decline by 50%). The human body has multiple mechanisms ( hepatic, renal, etc.) that allow drugs and other substances to be eliminated from the body. As a result, immediately following the initial bolus dose, drug concentrations will begin to decline.
IS AUC EQUAL TO NEUROTRACKER SYSTEM FULL
Let’s assume we administer 500 mg of a drug into a hypothetical volume of 10 liters. Since the full IV bolus dose is administered at once, we will see an initial concentration of 50 mg/L (500 mg/10 L of volume = 50 mg/L). Single-Dose PK Behaviorįor the purpose of this discussion, we will use single-dose IV bolus administration as the starting point. Most prescription drugs are administered repeatedly for a limited duration (for acute illnesses) or for an extended period of time (for chronic conditions). As such, it is important to understand the pharmacokinetic (PK) behavior of drugs when they are administered according to repeat-dose regimens. Content last updated on November 19, 2021
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